[Binding of cefuroxime to macromolecules from bronchitic sputum in patients with chronic bronchitis]

Cefuroxime binding to soluble bronchial macromolecules has been performed in vitro with preparations obtained from ten patients. Cefuroxime at various concentrations have been added to soluble macromolecules (10 g/l). Free cefuroxime has been obtained by equilibrium dialysis and measured by HPLC. Results show that cefuroxime binding is about 30% of total antibiotic.