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[Diffusion of roxithromycin in gingival tissue].

F Jehl1, R Kolbe, P Chrétien

  • 1Faculté de Médecine, Institut de Bactériologie, Strasbourg.

Pathologie-Biologie
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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Roxithromycin effectively penetrates gingival tissues, maintaining concentrations above the minimum inhibitory level for common oral pathogens for several hours after administration. This study evaluated its steady-state gingival penetration in patients.

Area of Science:

  • Pharmacokinetics
  • Microbiology
  • Oral Medicine

Context:

  • Gingival penetration of antibiotics is crucial for treating stomatologic infections.
  • Roxithromycin is a macrolide antibiotic with potential applications in oral infections.
  • Understanding drug concentration at the infection site is key for therapeutic efficacy.

Purpose:

  • To evaluate the gingival tissue penetration of roxithromycin at steady-state.
  • To determine roxithromycin concentrations in gingival tissue and serum over time.
  • To compare tissue concentrations with the minimum inhibitory concentration (MIC 90) for relevant pathogens.

Summary:

  • Twenty-nine patients received 150 mg of roxithromycin orally every 12 hours for five days.
  • Gingival tissue and serum samples were collected at various time points after the 10th dose.

Related Experiment Videos

  • High-performance liquid chromatography (HPLC) was used to measure drug concentrations.
  • Serum peak concentration was 6.60 ± 1.15 µg/ml at 4 hours.
  • Gingival tissue peak concentration was 4.63 ± 1.84 µg/g at 8 hours.
  • Tissue concentrations remained above 2 µg/g between 4 and 10 hours post-administration.

    • Impact:

    • Gingival tissue concentrations of roxithromycin exceeded MIC 90 for many stomatologic pathogens.
    • Results suggest roxithromycin's potential efficacy in treating oral infections due to adequate tissue penetration.
    • Provides pharmacokinetic data supporting the use of roxithromycin in dental and oral infections.