[Role of the destructive phase of regeneration in reparative osteogenesis]

Experiments were conducted on mongrel male rats to study the dependence of the character of maxillary fracture consolidation on the content of osteo-inducing (01) and osteo-inhibiting (I) proteins in the bone tissue as well as the effect of agents intensifying (parathormone) or reducing (methyluracil) the resorption phase of bone regeneration. It is shown that the ratio of OI and I proteins in the bone tissue determines the healing of the fracture according to the type of uncomplicated or slow consolidation in untreated animals, whereas parathormone administration increases the number of animals with uncomplicated consolidation of the fracture and raises the strength of union of the fragments. Methyluracil fails to produce such on effect. It is suggested that improved regeneration of bone in intensification of the phase of resorption is due to more effective excretion of OI proteins from the injured bone tissue.