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Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Mapping MHC genes in river buffalo.

E A Rodrigues Filho, N B Stafuzza, A R Caetano

    Developments in Biologicals
    |September 27, 2008
    PubMed
    Summary
    This summary is machine-generated.

    The major histocompatibility complex (MHC) in river buffalo is organized similarly to cattle, with genes located on chromosome 2. This study mapped MHC class II genes, providing insights into buffalo immune system genetics.

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    Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

    Published on: December 23, 2016

    Area of Science:

    • Genomics
    • Immunology
    • Comparative genetics

    Background:

    • The Major Histocompatibility Complex (MHC) is crucial for immune function and animal health.
    • MHC genes are highly polymorphic and located in a gene-dense region of the mammalian genome.
    • Previous studies suggested the river buffalo MHC is on chromosome 2 (BBU2).

    Purpose of the Study:

    • To determine the general organization of the MHC on river buffalo chromosome 2 (BBU2).
    • To compare the gene order of the river buffalo MHC with that of cattle.
    • To map MHC class II genes in river buffalo using a radiation hybrid panel.

    Main Methods:

    • Utilized a 5000-rad radiation hybrid mapping panel (BBURH5000) for river buffalo.
    • Employed PCR primers derived from the bovine gene map.
    • Mapped ten MHC class II genes in river buffalo.

    Main Results:

    • River buffalo MHC class II genes were found in two distinct linkage groups.
    • This organization is consistent with the known MHC organization in cattle.
    • The study provides the first comparative gene order analysis of the MHC in river buffalo and cattle.

    Conclusions:

    • The MHC in river buffalo shares a similar gene organization with cattle on chromosome 2.
    • This research offers foundational insights into the river buffalo MHC structure and its evolutionary implications.
    • Comparative mapping aids in understanding immune gene organization across species.