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Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Related Experiment Video

Updated: Jun 30, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

[An effective combined therapy for simple premature ejaculation].

Jing-Tang Pei1, Zhao-Hui Shi

  • 1Teaching and Research Section of Surgery, Huaihe Clinical School, Henan University, Kaifeng, Henan 475001, China. PJT1957@sohu.com

Zhonghua Nan Ke Xue = National Journal of Andrology
|September 27, 2008
PubMed
Summary
This summary is machine-generated.

A combined therapy improved treatment outcomes for premature ejaculation. This approach, integrating medication, traditional Chinese medicine, and psychological guidance, demonstrated sustained effectiveness over time.

Related Experiment Videos

Last Updated: Jun 30, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Integrative medicine
  • Sexual health
  • Clinical pharmacology

Context:

  • Premature ejaculation (PE) is a common male sexual dysfunction.
  • Current treatments for PE have varying efficacy and side effect profiles.
  • There is a need for more effective and stable treatment options for PE.

Purpose:

  • To evaluate the clinical efficacy and stability of a combined therapy for simple premature ejaculation.
  • To compare the combined therapy with standard pharmacotherapy alone.

Summary:

  • A study involving 110 patients with simple premature ejaculation compared a combined therapy group (sertraline, traditional Chinese medicine, psychological guidance) with a control group (sertraline only).
  • The combined therapy group showed significantly higher total effectiveness rates (91.6% vs. 76%) at 4 weeks and sustained improvement (68.3% vs. 42%) after drug withdrawal compared to the control group.
  • Ejaculation latency and sexual life satisfaction were key outcome measures.

Impact:

  • The combined therapy offers a promising and stable treatment strategy for simple premature ejaculation.
  • This multimodal approach may enhance patient outcomes and long-term satisfaction.
  • Findings support the integration of psychological and traditional medicine interventions in managing PE.