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Risk Factors for Severe Allergic Rhinitis and the Association with Serum-Specific Immunoglobulin E Levels: A Study in
Feng-Wen Shan1,2,3, Min Zhou4, Xin-Yi Zheng5
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, shanfw@mail2.sysu.edu.cn.
Introduction:
The meticulous management of risk factors is paramount in the effective control of allergic rhinitis (AR), playing a significant role in diminishing both the direct medical expenditures and the indirect economic impacts associated with the condition. Presently, there is a notable deficiency in research concerning the risk factors for severe AR, as well as the correlation between serum allergen-specific immunoglobulin E (sIgE) levels and the severity of AR symptoms.
Methods:
The study utilized data from a cross-sectional epidemiological survey conducted in Guangzhou, China, from April 2023 to March 2024, involved 638 AR patients. We used Visual Analogue Scale (VAS) scores to assess the severity of AR. Data of daily risk factors were collected through face-to-face questionnaires, and serum sIgE levels were measured using the AllergyScreen assay (Mediwiss Analytic GmbH, Moers, Germany). A generalized linear model was used to investigate the associations.
Results:
Our findings indicate that patients with severe AR exhibited more unhealthy lifestyle habits and lived in high-risk environments compared to non-severe patients. Physical activity more than three times per week was associated with a reduced risk of severe symptoms (OR: 0.55, 95% CI: 0.36, 0.82). Frequent indoor cleaning also lowered the risk of severe AR (OR: 0.70, 95% CI: 0.56, 0.87). Additionally, a one-level increase in serum sIgE was linked to higher odds of severe AR (OR: 1.26, 95% CI: 1.11, 1.43) after adjusting for risk factors.
Conclusion:
Severe AR is associated with poor household cleaning and less exercise. Higher serum sIgE levels correspond to a higher risk of severe AR.
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