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Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000-2018)
Ning Kang1,2,3, Man-Hou Chao3,4, Xin Luo1,2,3
1Department of Otolaryngology-Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou China.
Summary
Urbanization significantly increased eosinophilic chronic rhinosinusitis (CRS) prevalence and inflammation in Guangzhou. Rising population density and motor vehicle ownership correlate with worsening CRS pathology.
Area of Science:
- Otolaryngology
- Pathology
- Environmental Health
Background:
- Chronic rhinosinusitis (CRS) shows diverse pathological endotypes with unclear causes.
- Current methods for determining CRS endotypes require accuracy optimization.
Purpose of the Study:
- To investigate the temporal trends and pathological changes in CRS.
- To assess the correlation between CRS progression and urbanization indicators.
Main Methods:
- Retrospective analysis of 970 CRS patients in Guangzhou (2000-2018).
- Division into five biennial cohorts for demographic, clinical, and pathological data analysis.
- Artificial intelligence-based whole-slide imaging for pathological assessment and correlation with urbanization indicators.
Main Results:
- Allergic comorbidity in CRS patients increased from 5.38% to 15.36%.
- Eosinophil density surged from 7.58 to 265.98 counts/mm², with eosinophilic CRS prevalence rising to 40.85%.
- Urbanization indicators, particularly motor vehicle ownership and population density, strongly correlated with inflammation and eosinophilia.
Conclusions:
- CRS patients in Guangzhou exhibit increasing inflammation and eosinophilic infiltration.
- Urbanization, especially population density, is linked to CRS inflammatory profile shifts and rising allergic comorbidities.
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