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Related Experiment Video

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Artificial Intelligence-Based Pathological Subtype Diagnosis of Nasal Polyps: A Multidimensional and

Xin Luo1,2,3,4, Hansheng Li5, Jianning Chen6

  • 1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Allergy
|March 8, 2026
PubMed
Summary
This summary is machine-generated.

An AI system (NPSS) accurately diagnoses nasal polyp subtypes and predicts recurrence by integrating microscopic (MI) and whole-slide imaging (WSI). This AI tool significantly reduces diagnostic time and improves accuracy for pathologists.

Keywords:
artificial intelligencemicroscopic imagenasal polyppathologywhole slide image

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Area of Science:

  • Otorhinolaryngology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Nasal polyps (NP) present diverse inflammatory subtypes impacting clinical outcomes.
  • Manual cell counting in microscopic images (MI) is time-consuming and subjective.
  • Current methods limit diagnostic precision for NP subtypes and treatment decisions.

Purpose of the Study:

  • To develop an AI-based system (NPSS) for accurate NP subtype diagnosis.
  • To enhance diagnostic efficiency and precision using artificial intelligence.
  • To predict NP recurrence using integrated imaging data.

Main Methods:

  • Developed NPSS using 2457 slides from 20 hospitals, incorporating MI and whole-slide imaging (WSI).
  • Employed PA-P2PNet for cell detection and U-KAN for region segmentation in NPSS-WSI.
  • Utilized 3D reconstruction (3DNP) for spatial cell quantification and logistic regression for recurrence prediction.

Main Results:

  • NPSS achieved high performance (F1-score 0.809, IoU 0.827) on internal and external datasets.
  • NPSS significantly reduced diagnostic time (e.g., WSI from 10,450s to 250s) and improved pathologist accuracy.
  • The NPSS-WSI prognostic model showed superior predictive performance (AUC 86.64%) compared to MI-based models.

Conclusions:

  • NPSS integrates MI, WSI, and 3DNP for precise NP subtype diagnosis and prognosis.
  • The AI system enhances diagnostic efficiency and clinical utility in managing nasal polyps.
  • NPSS represents a significant advancement in the objective assessment and management of nasal polyps.