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Updated: Jun 30, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
[Auto-inflammatory syndromes and pregnancy].
Katia Stankovic1, Véronique Hentgen, Gilles Grateau
1Service de Médecine Interne, Centre de Référence des Amyloses d'Origine Inflammatoire et de la Fièvre Méditerranéenne Familiale, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Université Paris 6, Paris Cedex 20, France. katia.stankovic@tnn.aphp.fr
Presse Medicale (Paris, France : 1983)
|September 27, 2008
Summary
Familial Mediterranean Fever (FMF) patients on colchicine have normal fertility and safe breastfeeding. Continuing treatment during pregnancy is recommended to reduce abortion risk, with careful monitoring for those with renal amyloidosis.
Area of Science:
- Reproductive medicine
- Genetics and hereditary diseases
- Pharmacology
Context:
- Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder.
- Management of FMF often involves long-term colchicine therapy.
- Reproductive health in FMF patients requires specific consideration.
Purpose:
- To evaluate the impact of colchicine treatment on fertility and pregnancy outcomes in FMF patients.
- To provide guidance on managing FMF during conception, pregnancy, and breastfeeding.
- To assess the safety of continuing colchicine therapy in FMF patients.
Summary:
- Fertility is generally normal in FMF patients undergoing colchicine treatment, with no adverse effects on spermatogenesis.
- Continuing colchicine during pregnancy is advised to mitigate the increased risk of early abortion associated with inflammatory attacks.
- Breastfeeding is safe for infants whose mothers are treated with colchicine, and routine amniocentesis is not indicated for treated FMF patients.
Impact:
- Colchicine treatment allows for normal fertility and safe pregnancy in FMF patients.
- Continued colchicine therapy during pregnancy reduces pregnancy complications and ensures maternal health.
- This guidance supports optimal reproductive health and family planning for individuals with FMF.
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