Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Resting fMRI functional connectivity reflects fluctuations in inhibitory interneuron activity.

bioRxiv : the preprint server for biology·2026

Same author

Ventrolateral prefrontal cortex in macaques guides decisions in different learning conditions.

Nature communications·2026

Same author

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.

Nature neuroscience·2026

Same author

During natural vision, semantic novelty modulates fixation-related processing in primate cortex.

bioRxiv : the preprint server for biology·2026

Same author

Auditory categories in the nonhuman primate.

Handbook of behavioral neuroscience·2026

Same author

Dose-dependent power and connectivity modulation of low frequency oscillations through transcranial magnetic stimulation in non-human primates.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

A Two-interval Forced-choice Task for Multisensory Comparisons

A Two-interval Forced-choice Task for Multisensory Comparisons

Published on: November 9, 2018

Prefrontal neurons predict choices during an auditory same-different task.

Brian E Russ¹, Lauren E Orr, Yale E Cohen

¹Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA.

Current Biology : CB

|September 27, 2008

Summary

Animals must detect stimuli for survival but not react to all. The prefrontal cortex (PFC) is key for context-dependent responses to uncommon stimuli, linking neural activity to behavioral choices.

More Related Videos

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Related Experiment Videos

Last Updated: Jun 30, 2026

A Two-interval Forced-choice Task for Multisensory Comparisons

A Two-interval Forced-choice Task for Multisensory Comparisons

Published on: November 9, 2018

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Area of Science:

Neuroscience
Cognitive Neuroscience
Animal Behavior

Background:

Stimulus detection is vital for survival, but automatic responses to all environmental stimuli are maladaptive.
The prefrontal cortex (PFC) is recognized for its role in executive functions, suggesting involvement in regulated stimulus responses.

Purpose of the Study:

To investigate the role of the ventrolateral prefrontal cortex (vPFC) in context-dependent responses to auditory stimuli.
To test the hypothesis that PFC activity is involved in processing uncommon stimuli within a specific context.

Main Methods:

Monkeys performed a same-different task, a variation of an oddball task, discriminating between reference and test auditory stimuli.
Neuronal activity was recorded from the ventrolateral prefrontal cortex (vPFC) during task performance.

Main Results:

vPFC neuronal activity was found to be correlated with the monkeys' behavioral choices.
This indicates a direct relationship between neural activity in the vPFC and decision-making in a nonspatial auditory task.

Conclusions:

Single neurons in the vPFC are directly linked to behavioral choices in nonspatial auditory tasks.
The findings support the hypothesis that the PFC is involved in context-dependent processing of stimuli and executive control.