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Updated: Jun 30, 2026

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
Published on: March 9, 2015
On the measurement of the functional properties of the CFTR
Oscar Moran1, Olga Zegarra-Moran
1Istituto di Biofisica, CNR, 16149 Genova, Italy. moran@ge.ibf.cnr.it
Abstract:
A number of methods are currently employed to assess the functional properties of CFTR channels and their response to pharmacological potentiators, correction of the defective CFTR trafficking, and vectorial introduction of new proteins. Here we review the most common methods used to assess CFTR channel function. The suitability of each technique to various experimental conditions is discussed.
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