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[Left ventricular diastolic function in subjects with arterial hypertension living in the Far North depending on the

I L Zapesochnaia, A G Avtandilov

    Klinicheskaia Meditsina
    |September 30, 2008
    PubMed

    Insights

    Shift work in arterial hypertension (AH) patients living in the Far North is linked to impaired left ventricular diastolic function (LVDF). Night shift workers showed more LVDF disturbances, particularly affecting left ventricle filling and related to hypertrophy.

    Area of Science:

    • Cardiology
    • Environmental Medicine
    • Occupational Health

    Background:

    • Arterial hypertension (AH) poses significant health risks, especially in challenging environments like the Far North.
    • Working regimes, such as shift work, may influence cardiovascular health in individuals with AH.
    • Left ventricular diastolic function (LVDF) is a critical indicator of cardiac health, often affected by hypertension.

    Purpose of the Study:

    • To investigate the impact of working regimes on LVDF in patients with arterial hypertension (AH) residing in the Far North.
    • To compare LVDF between day workers and shift workers with AH.
    • To explore the relationship between LVDF, left ventricular hypertrophy, and nocturnal blood pressure in AH patients.

    Main Methods:

    • Doppler echocardiography was used to assess LVDF in 95 patients with grade I-II AH and 25 healthy controls.
    • Patients were categorized into dayworkers (n=53) and shift workers (n=42).
    • Analysis correlated LVDF parameters with working regime, left ventricular hypertrophy, and arterial pressure.

    Main Results:

    • Shift workers with AH exhibited a higher prevalence of LVDF disturbances compared to day workers and controls.
    • Key disturbances included an increased contribution of left atrial systole to left ventricle filling.
    • LVDF was significantly dependent on the degree of left ventricular hypertrophy and elevated nocturnal systolic arterial pressure.

    Conclusions:

    • Shift work, particularly night shifts, is associated with compromised LVDF in individuals with arterial hypertension in the Far North.
    • LVDF impairments in AH patients are linked to ventricular hypertrophy and nocturnal hypertension.
    • Occupational health strategies should consider the impact of shift work on cardiovascular function in hypertensive populations.

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