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Updated: Jun 30, 2026
05:31
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
[Pregnancy and vasculitides]
1Pôle de Médecine Interne, Centre de Référence Groupe I Maladies Rares, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris Cedex 14, France. christian.pagnoux@cch.aphp.fr
Presse Medicale (Paris, France : 1983)
|September 30, 2008
Summary
Systemic vasculitides can affect women of childbearing age. While pregnancy may not significantly impact vasculitis, specialized management is crucial for optimal maternal and fetal outcomes.
Area of Science:
- Rheumatology and Immunology
- Maternal-Fetal Medicine
- Systemic Autoimmune Diseases
Context:
- Systemic vasculitides affect women of childbearing potential.
- Pregnancies in these patients are rare due to disease rarity, historical fatality, and toxic treatments.
- Pregnancy may not significantly alter vasculitis course, unlike lupus, but requires specialized care.
Purpose:
- To review the management of pregnancy in women with systemic vasculitis.
- To highlight the importance of pre-conception planning and disease remission.
- To discuss treatment options and safety considerations during pregnancy.
Summary:
- Pregnancy can reveal or occur in women with systemic vasculitis, necessitating careful monitoring.
- Planned pregnancies during disease remission with cessation of toxic immunosuppressants are ideal.
- Management involves addressing vasculitis sequelae and selecting appropriate treatments, balancing risks and benefits.
Impact:
- Highlights the need for multidisciplinary care for pregnant women with vasculitis.
- Informs clinical practice regarding treatment choices and timing during pregnancy.
- Emphasizes the importance of risk-benefit assessment for immunosuppressive therapies in this population.
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