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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Persistent pulmonary interstitial emphysema in a preterm infant
Ahmet Yagmur Bas1, Nurullah Okumus, Nihal Demirel
1Neonatology Unit, Sanliurfa Obstetrics and Gynecology Hospital, Sanliurfa, Turkey. yagmur32@yahoo.com
Persistent pulmonary interstitial emphysema, a chronic lung disease, can occur in premature infants. This case shows localized disease resolving without mechanical ventilation or surgery.
Area of Science:
- Neonatology
- Pediatric Pulmonology
- Critical Care Medicine
Background:
- Persistent pulmonary interstitial emphysema (PPIE) is a known complication in mechanically ventilated premature neonates.
- It is characterized by air trapping within the pulmonary interstitium, leading to respiratory distress.
Observation:
- This report details a rare case of localized PPIE in a preterm infant.
- The infant received continuous positive airway pressure (CPAP) via nasal prongs but was not mechanically ventilated.
Findings:
- The localized PPIE in this non-ventilated preterm infant demonstrated a favorable outcome.
- The condition resolved spontaneously without the need for surgical intervention.
Implications:
- This case suggests that PPIE may occur in preterm infants receiving non-invasive respiratory support like CPAP.
- It highlights the potential for conservative management and resolution of PPIE, even in localized forms, challenging the necessity of mechanical ventilation in all cases.
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