Related Experiment Videos
Effects of Fe2+, Fe3+ and desferrioxamine on paraquat accumulation by rabbit kidney cortex slices
Y Fujimoto1, M Yokota, Y Ohdate
1Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan.
Abstract:
Effects of Fe2+, Fe3+ and desferrioxamine (DFO) on the accumulation of paraquat (PQ) into rabbit kidney cortical slices were studied. Fe3+ showed dose-dependent inhibition of PQ accumulation. Fe2+ had a more powerful stimulatory effect on the lipid peroxidation of cortical slices than Fe3+, but it did not reduce PQ accumulation. The addition of DFO made the inhibitory effect of Fe3+ on PQ accumulation more pronounced. These results suggest that Fe3+ is able to inhibit the accumulation of PQ independent of its peroxidative action, and that Fe(3+)-desferrioxamine (ferrioxamine) may serve as an antidote for the toxicity of PQ.