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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos
08:37

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

MicroRNAs in embryonic stem cells.

Yulei Wang1, David N Keys, Janice K Au-Young

  • 1Gene Expression and Genotyping Assays R&D, Molecular Cell Biology Division, Applied Biosystems, Foster City, California, USA.

Journal of Cellular Physiology
|September 30, 2008
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells (ESCs) can self-renew and differentiate, offering regenerative medicine potential. MicroRNAs (miRNAs) are key regulators in ESC maintenance and development, with ongoing research exploring their crucial roles.

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In ovo Expression of MicroRNA in Ventral Chick Midbrain
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In ovo Expression of MicroRNA in Ventral Chick Midbrain
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In ovo Expression of MicroRNA in Ventral Chick Midbrain

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Area of Science:

  • Stem cell biology
  • Molecular biology
  • Epigenetics

Background:

  • Embryonic stem cells (ESCs) possess unique self-renewal and differentiation capabilities.
  • These properties hold significant promise for regenerative medicine applications.
  • MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression.

Purpose of the Study:

  • To review recent advancements in understanding miRNA roles in ESCs.
  • To highlight the significance of miRNAs in ESC maintenance.
  • To explore the involvement of miRNAs in ESC development.

Main Methods:

  • Literature review of recent studies on miRNAs and ESCs.
  • Analysis of experimental data characterizing miRNA functions.
  • Synthesis of current knowledge on miRNA-mediated gene regulation in ESCs.

Main Results:

  • miRNAs play crucial roles in regulating ESC self-renewal.
  • miRNAs are essential for controlling ESC differentiation pathways.
  • Specific miRNAs have been identified as key players in ESC pluripotency.

Conclusions:

  • miRNAs are integral to maintaining the unique characteristics of ESCs.
  • Targeting miRNAs could offer novel therapeutic strategies in regenerative medicine.
  • Further research into miRNA-ESC interactions is vital for clinical translation.