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Related Experiment Video

Updated: Jun 30, 2026

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

Estrogen, testosterone, and sequential movement in men.

Jessica A Siegel¹, Laura A Young, Michelle B Neiss

¹Department of Behavioral Neuroscience, Oregon Health & Science University, USA.

Behavioral Neuroscience

|October 1, 2008

Summary

This summary is machine-generated.

Sex hormones do not appear to influence sequential movement in men. Hormone manipulation did not affect movement speed or accuracy in older or younger men, suggesting replacement therapy may not help with age-related decline.

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Area of Science:

Neuroscience
Endocrinology
Human Movement Science

Background:

The striatal dopaminergic system is crucial for sequential movement execution.
Striatal function is modulated by sex hormones, with estradiol linked to sequential movement in women.

Purpose of the Study:

To investigate the role of sex hormones in the production of sequential movement in healthy older and younger men.
To determine if hormone manipulation affects sequential movement performance in men.

Main Methods:

Healthy older and younger men underwent a 6-week hormone manipulation protocol (testosterone modification, estradiol conversion blockade, testosterone production blockade, or placebo).
Sequential movement tasks were assessed before and after the intervention period.

Main Results:

Older men exhibited slower and more accurate sequential movement than younger men, both pre- and post-treatment.
Hormone manipulation did not significantly alter movement speed or accuracy in either age group.
No correlation was found between hormone levels and sequential movement performance.

Conclusions:

Sex hormones do not appear to modulate sequential movement abilities in men.
Hormone replacement therapy is unlikely to restore age-related deficits in sequential movement or benefit men with Parkinson's disease.