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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Microbial Bioremediation of Plastics01:28

Microbial Bioremediation of Plastics

Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Designed for Molecular Recycling: A Lignin-Derived Semi-aromatic Biobased Polymer
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Designed for Molecular Recycling: A Lignin-Derived Semi-aromatic Biobased Polymer

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Biodegradable poly(polyol sebacate) polymers.

Joost P Bruggeman1, Berend-Jan de Bruin, Christopher J Bettinger

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton Street, E25-342, Cambridge, MA 02139, USA.

Biomaterials
|October 1, 2008
PubMed
Summary
This summary is machine-generated.

Researchers created tunable, biodegradable poly(polyol sebacate) (PPS) polymers from metabolism-based units. These novel polymers show promising tunable mechanical properties and biocompatibility for potential biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Synthetic biodegradable polymers are crucial for medical applications.
  • Existing polymers like PLGA have limitations that necessitate new material development.
  • Polymers derived from endogenous metabolic units offer potential for improved biocompatibility and tailored degradation.

Purpose of the Study:

  • To develop and characterize a novel family of synthetic biodegradable polymers, poly(polyol sebacate) (PPS) polymers.
  • To investigate the tunability of PPS polymer properties through variations in monomer composition and stoichiometry.
  • To evaluate the degradation profiles and biocompatibility of PPS polymers in comparison to established biomaterials.

Main Methods:

  • Synthesis of poly(polyol sebacate) (PPS) polymers using varying polyol monomers and sebacic acid ratios.
  • Characterization of mechanical properties, including tensile Young's moduli and elongation at break.
  • Determination of glass transition temperatures (Tg) using thermal analysis.
  • In vitro and in vivo degradation studies under physiological conditions.
  • In vitro and in vivo biocompatibility assessments, comparing PPS to PLGA.

Main Results:

  • PPS polymers exhibited a wide range of tunable mechanical properties, with Young's moduli from 0.37 to 378 MPa and elongations at break from 11% to 205%.
  • Glass transition temperatures varied between approximately 7°C and 46°C, indicating adaptable thermal characteristics.
  • In vitro degradation rates were slower than in vivo rates for some PPS polymers.
  • PPS polymers demonstrated comparable in vitro and in vivo biocompatibility to poly(L-lactic-co-glycolic acid) (PLGA).

Conclusions:

  • Poly(polyol sebacate) (PPS) polymers represent a versatile new class of synthetic biodegradable materials.
  • The tunable mechanical and thermal properties, along with favorable biocompatibility, make PPS polymers promising for various biomedical applications.
  • Further research into degradation kinetics and in vivo performance is warranted to fully realize the potential of PPS polymers.