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Related Concept Videos

Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
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Related Experiment Video

Updated: Jun 30, 2026

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

[Update on the progestin-only contraception].

P Madelenat1, M Koskas,

  • 1Clinique de la Muette, 46, rue Nicolo, 75016 Paris, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|October 1, 2008
PubMed
Summary
This summary is machine-generated.

Progestin-only contraceptives are increasingly used, with expert guidance addressing clinical questions. Evidence does not link progestogen use to increased breast cancer or fracture risks.

Related Experiment Videos

Last Updated: Jun 30, 2026

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

Area of Science:

  • Reproductive Endocrinology
  • Contraceptive Technology
  • Clinical Pharmacology

Context:

  • Increasing use of progestin-only contraceptives (POCs) in France, including IUDs, implants, and microprogestins.
  • Prescriptions often involve diverse molecules and dosages, sometimes off-label.
  • Need for expert consensus on controversial clinical practice points regarding POCs.

Purpose:

  • To address 35 questions posed by an Expert Organization Board regarding progestin-only contraception.
  • To provide evidence-based answers, supplemented by expert consensus where data is lacking.
  • To clarify the safety and efficacy of various progestin-only methods.

Summary:

  • POCs act locally and/or centrally, with efficacy generally satisfactory but requiring strict adherence (especially microprogestins).
  • No demonstrated link between progestogen use and increased breast cancer risk; bone density and fracture risks are not directly associated with POCs.
  • Progestogens are not considered risk factors for venous thromboembolism.

Impact:

  • Provides clinical guidance for healthcare providers managing progestin-only contraception.
  • Clarifies safety profiles regarding breast cancer, bone density, and thromboembolism.
  • Identifies specific patient populations and conditions where POCs are recommended, including breastfeeding and adenomyosis.