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Published on: May 19, 2023
[Optimization for formulation matrix proportion of xiangyu cataplasm by uniform design]
Ke Xu1, Pei-Hu Xu, Xue-Qiong Zhang
1Wuhan University of Technology, Wuhan 430070, China. xuke_coco@163.com
Summary
This study optimized a cataplasm matrix for infantile diarrhea, finding a specific formulation that is safe and effective for transdermal drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Context:
- Infantile diarrhea requires effective treatment options.
- Transdermal drug delivery systems offer a non-invasive approach.
Purpose:
- To optimize the matrix formulation of a cataplasm for treating infantile diarrhea.
- To identify the ideal component proportions for enhanced efficacy and stability.
Summary:
- Utilized uniform design and SPSS regression analysis to determine optimal matrix proportions.
- The best matrix composition included gelatin, CMC-Na, PANA, kaolin, aluminum trichloride, citric acid, PVP K-30, PEG400, trimethylene glycol, and tween-80.
- Evaluated key parameters such as adhibition, peeling strength, non-flowing properties, and cream content.
Impact:
- Establishes a feasible and controllable preparation technique for cataplasms.
- Demonstrates the potential of this cataplasm as a safe and effective transdermal drug delivery system for infantile diarrhea.
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