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Juvenile polyposis syndrome affecting the stomach: a case report
Steven Kelly1, Simon Dwerryhouse, Peter Safranek
1Cambridge Oesophagogastric surgery centre, Addenbrookes hospital, Cambridge, UK. stevekelly999@btinternet.com
Journal of Medical Case Reports
|October 2, 2008
Summary
Juvenile polyposis syndrome (JPS) can uncommonly manifest as massive gastric polyposis. This case highlights surgical management of severe gastric polyps in JPS.
Area of Science:
- Gastroenterology
- Genetics
- Surgical Pathology
Background:
- Juvenile polyposis syndrome (JPS) is a rare autosomal dominant disorder.
- Characterized by hamartomatous polyps throughout the gastrointestinal tract, predominantly in the colon.
- Massive gastric polyposis is an unusual presentation of JPS.
Purpose of the Study:
- To report an atypical case of JPS presenting with extensive gastric polyposis.
- To discuss the diagnostic and management challenges of massive gastric polyposis in JPS.
Main Methods:
- Case report of a 51-year-old male with JPS.
- Presentation with gastric outlet obstruction and upper gastrointestinal bleeding.
- Diagnostic procedures included gastroscopy and histology; management involved endoscopic polypectomy and total gastrectomy.
Main Results:
- Gastroscopy revealed massive gastric polyposis with a prolapsed antral polyp causing obstruction.
- Initial endoscopic polypectomy was insufficient.
- Histology confirmed massive gastric juvenile polyposis, necessitating total gastrectomy.
Conclusions:
- Massive gastric polyposis is a rare but significant manifestation of JPS.
- This case underscores the importance of considering surgical intervention for severe gastric involvement in JPS.
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