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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Updated: Jun 29, 2026

Isolation and Identification of Bacterial Strains from Skin of Terrestrial Amphibians
05:19

Isolation and Identification of Bacterial Strains from Skin of Terrestrial Amphibians

Published on: June 17, 2025

Agents from amphibians with anticancer properties.

Chuang-Xin Lu1, Ke-Jun Nan, Yan Lei

  • 1Cancer Center of The First Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shanxi Province, China.

Anti-Cancer Drugs
|October 2, 2008
PubMed
Summary
This summary is machine-generated.

Amphibians yield potent anticancer agents like bufalin and cytotoxic peptides. These natural compounds, including RNase A family members, show significant medical and pharmaceutical promise for cancer treatment.

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Published on: June 26, 2018

Area of Science:

  • Biochemistry
  • Pharmacology
  • Zoology

Background:

  • Amphibians are a rich source of bioactive compounds with therapeutic potential.
  • Anticancer properties have been identified in various amphibian-derived molecules, including peptides and small compounds.
  • These natural agents offer novel mechanisms for combating cancer.

Purpose of the Study:

  • To explore the anticancer properties of amphibian-derived products.
  • To discuss the medical and pharmaceutical significance of these natural agents.
  • To highlight the potential of amphibian compounds in cancer therapy.

Main Methods:

  • Review of existing literature on amphibian-derived anticancer agents.
  • Identification and characterization of specific compounds like bufalin and amphibian peptides (magainins, aureins, citropin 1.1, gaegurins).
  • Analysis of cytotoxic mechanisms, including apoptosis induction and RNA degradation by RNase A family members (Onconase, amphinase, cSBL, jSBL).

Main Results:

  • Bufalin demonstrates anticancer activity, potentially through apoptosis induction.
  • Amphibian skin peptides exhibit cytotoxic effects on human cancer cells via diverse mechanisms.
  • RNase A family members purified from amphibian eggs induce cytotoxicity by degrading cellular RNA.

Conclusions:

  • Amphibian-derived products possess significant anticancer properties.
  • These natural compounds, including peptides and enzymes, hold considerable medical and pharmaceutical importance.
  • Further research into amphibian-derived agents could lead to novel cancer therapeutics.