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CD90 mediates gastric cancer immune evasion though regulating IGF2BP2 to stabilize the m6A-CD47/SIRPα axis

Siyi Liu1,2, Lin Liang1,2, Zihua Zhou3

  • 1Department of Nuclear Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital & Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.

Cancer Cell International
|July 1, 2026
PubMed

Insights

CD90 promotes gastric cancer immune evasion by inhibiting macrophage phagocytosis via the IGF2BP2-CD47 axis. This study reveals CD90 as a potential therapeutic target for gastric cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • CD90 (Thy-1) is a cell surface glycoprotein implicated in cancer progression.
  • Its role in gastric cancer (GC) immune evasion remains unclear.
  • Understanding CD90's function is crucial for developing novel GC therapies.

Purpose of the Study:

  • To investigate the role of CD90 in gastric cancer immune evasion.
  • To elucidate the molecular mechanisms by which CD90 mediates immune evasion.
  • To explore CD90 as a potential therapeutic target for GC.

Main Methods:

  • Analysis of CD90 expression in GC tissues.
  • Assessment of the correlation between CD90 and macrophage infiltration.
  • Investigation of CD90's effect on tumor-associated macrophage (TAM) phagocytosis.
  • Molecular experiments to determine the CD90-IGF2BP2-CD47 signaling pathway.

Main Results:

  • CD90 is highly expressed in GC tissues and correlates with macrophage infiltration.
  • CD90 inhibits TAM phagocytic function, thereby mediating immune evasion.
  • CD90 acts as a scaffold, inhibiting IGF2BP2/TRIM21 interaction and stabilizing IGF2BP2.
  • IGF2BP2 enhances CD47 mRNA stability in an m6A-dependent manner, activating the CD47/SIRPα axis.

Conclusions:

  • The CD90-IGF2BP2-CD47 axis is critical for immune evasion in gastric cancer.
  • CD90 plays a significant role in suppressing anti-tumor immunity by impairing TAM function.
  • Targeting the CD90 pathway offers a promising strategy for GC immunotherapy.
Keywords:
CD47CD90Gastric cancerIGF2BP2Tumor immune evasion

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