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Updated: Jun 29, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological
Matthew C Loftspring1, Jeremiah McDole, Aigang Lu
1Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0536, USA.
Abstract:
Intracerebral hemorrhage (ICH) is a stroke subtype with high rates of mortality and morbidity. The immune system, particularly complement and cytokine signaling, has been implicated in brain injury after ICH. However, the cellular immunology associated with ICH has been understudied. In this report, we use flow cytometry to quantitatively profile immune cell populations that infiltrate the brain 1 and 4 days post-ICH. At 1 day CD45(hi) GR-1(+) cells were increased 2.0-fold compared with saline controls (P
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