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Learning in the 2-bottle alcohol preference test.

David A Blizard¹, David J Vandenbergh, Arimantas Lionikas

¹Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA. dab22@psu.edu

Alcoholism, Clinical and Experimental Research

|October 3, 2008

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Mice learn to adjust their alcohol preference (AP) during two-bottle tests. Their ability to adapt improves with experience, influencing AP scores over time.

Area of Science:

Neuroscience
Animal Behavior

Background:

The two-bottle preference test is widely used to study rodent solution selection.
The role of learning within this preference testing paradigm remains under-explored.

Purpose of the Study:

To investigate the influence of learning on two-bottle alcohol preference (AP) in mice.
To characterize how adaptation to changing fluid availability occurs during the test.

Main Methods:

Mice were exposed to a 15-day protocol involving daily or periodic interchanging of alcohol and water tubes.
Changes in AP were recorded across days and within distinct test periods.

Main Results:

Mice demonstrated improved adaptation to tube position changes with increased testing experience.

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Learning effects on AP varied based on initial preference scores, with low-AP mice decreasing AP and high-AP mice increasing AP over time.

Learning was observed in both inbred and genetically heterogeneous mouse populations.

Conclusions:

The study provides evidence for learning occurring within the two-bottle alcohol preference test.
Learning dynamics can significantly impact observed preference scores, independent of pre-test factors.
Understanding this learning phenomenon is crucial for elucidating the biobehavioral mechanisms of preference.