Related Experiment Video
Updated: Jul 1, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Looking Forward in Candidate Gene Research: Concerns and Suggestions
Gabriel L Schlomer1,2,3,2,4, H H Cleveland2, David J Vandenbergh3
1Department of Human Development and Family Studies and Department of Biobehavioral Health, 308 Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802.
Abstract:
Candidate Gene × Environment (cGxE) interaction research holds promise for helping us understand for whom and why environments matter for families and development. In their commentary on our target article (G. L. Schlomer, G. M. Fosco, H. H. Cleveland, D. J. Vandenbergh, & M. E. Feinberg, 2015), J. E. Salvatore and D. M. Dick (2015) present their view of the current state and future of cGxE research and frame the debate regarding its merits for advancing knowledge of gene-environment interplay. In this reply, we discuss points of agreement and departure and provide a list of 5 domains by which the quality of cGxE research should be evaluated. Our hope is that researchers will use this list as a guide for their own work.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Incomplete Dominance
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Gene Conversion
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

