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Updated: Jun 29, 2026

Determination of Glucan Chain Length Distribution of Glycogen Using the Fluorophore-Assisted Carbohydrate Electrophoresis (FACE) Method
Published on: March 31, 2022
FeCl3-catalyzed alpha-glycosidation of glycosamine pentaacetates
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Scienece, Chinese Academy of Sciences, Beijing 100085, China.
Abstract:
An efficient method for the large-scale preparation of alpha-N-acetylglycosaminides, such as fluorogenic T(N)-antigen probes and an alpha-GalNAc-Ser derivative, has been achieved using FeCl(3)-catalyzed one-step condensation between commercially available D-glycosamine pentaacetates and fluorogenic acceptors (or serine acceptor) in refluxing 1,2-dichloroethane. Experimental simplicity, high alpha-stereoselectivity, low cost, satisfactory yield, and the environmentally benign nature are major advantages of our approach.
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