Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy.

D A Palay1, P Sternberg, J Davis

  • 1Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322.

American Journal of Ophthalmology
|September 25, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secular trends in opportunistic infections, cancers and mortality in patients with AIDS during the era of modern combination antiretroviral therapy.

HIV medicine·2018
Same author

Insurance status and mortality among patients with AIDS.

HIV medicine·2017
Same author

Treatment of CMV retinopathy in patients with AIDS.

Ocular immunology and inflammation·2012
Same author

Takayansu's Arteritis Associated with Anterior Uveitis and Cutaneous Extravascular Necrotizing Granuloma.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.

Genes and immunity·2008
Same author

Maternal plasma cytokines in early- and mid-gestation of normal human pregnancy and their association with maternal factors.

Journal of reproductive immunology·2007
Same journal

Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

American journal of ophthalmology·2026
Same journal

Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

American journal of ophthalmology·2026
Same journal

Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

American journal of ophthalmology·2026
Same journal

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

American journal of ophthalmology·2026
See all related articles

Acyclovir treatment significantly protects the fellow eye from acute retinal necrosis (ARN). Patients receiving acyclovir had a much lower risk of developing ARN in their second eye compared to untreated patients.

Area of Science:

  • Ophthalmology
  • Virology
  • Infectious Diseases

Background:

  • Acute retinal necrosis (ARN) is a severe viral retinitis.
  • Unilateral ARN poses a risk of contralateral eye involvement.

Purpose of the Study:

  • To evaluate the efficacy of acyclovir in preventing fellow eye involvement in patients with unilateral ARN.

Main Methods:

  • Retrospective review of 54 patients with unilateral ARN.
  • Comparison of fellow eye disease-free rates between patients treated with acyclovir and those not treated.
  • Survival analysis to assess the impact of acyclovir on fellow eye protection.

Main Results:

  • Acyclovir-treated patients (n=31) had an 87.1% disease-free fellow eye rate versus 30.4% in untreated patients (n=23).

Related Experiment Videos

  • Survival analysis showed a significantly higher likelihood of fellow eye protection with acyclovir (P = .0013).
  • Two-year disease-free rates were 75.3% with acyclovir vs. 35.1% without.

    • Conclusions:

    • Acyclovir treatment is associated with a reduced risk of fellow eye involvement in ARN.
    • Early initiation of acyclovir may be crucial for preventing contralateral ARN.
    • This study supports the use of acyclovir for managing unilateral ARN.