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Updated: Jun 29, 2026
10:58
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
Published on: July 18, 2016
[Epithelial ovarian tumor microecology]
Johanne Leroy-Dudal1, Sabrina Kellouche, Pascal Gauduchon
1Laboratoire ERRMECe EA1391, Université de Cergy-Pontoise, UFR Sciences et Techniques, 2, avenue Adolphe-Chauvin, 95302 Cergy-Pontoise, France.
Bulletin Du Cancer
|October 3, 2008
Summary
Epithelial ovarian cancer (EOC) prognosis is poor due to late diagnosis and chemoresistance. Understanding the tumor microenvironment
Area of Science:
- Gynecological Oncology
- Cancer Biology
- Tumor Microenvironment Research
Context:
- Epithelial ovarian cancer (EOC) is a fatal malignancy with poor patient outcomes.
- Late diagnosis and acquired chemoresistance significantly contribute to EOC's poor prognosis.
- The tumor microenvironment (TME) plays a critical role in cancer development and progression.
Purpose:
- To review the critical role of the tumor microenvironment in epithelial ovarian cancer.
- To describe the molecular and cellular interactions between EOC cells and their microenvironment.
- To explore potential therapeutic strategies targeting the EOC microenvironment.
Summary:
- The TME comprises vascular components, stromal fibroblasts, inflammatory cells, and extracellular matrix.
- Multisite EOC development arises from cross-talk between cancer cells, stromal cells, and the extracellular matrix.
- These interactions involve cytokines, adhesion molecules, and proteolytic systems, influencing cancer progression.
Impact:
- Highlights the significance of tumor micro-ecology in epithelial ovarian cancer pathogenesis.
- Provides insights into the complex relationships governing EOC cell behavior within the TME.
- Suggests novel therapeutic avenues by targeting microenvironmental interactions for improved EOC treatment.
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