Ultrasound-guided biopsy of the thyroid: a comparison of technique with respect to diagnostic accuracy
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Updated: Jun 29, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
Karen E Schoedel1, Mitchell E Tublin, Karen Pealer
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. schoedelke@upmc.edu
Abstract:
Ultrasound-guided sampling of the thyroid represents a standard diagnostic procedure in the evaluation of thyroid nodules. The two techniques typically used are fine-needle aspiration and fine-needle capillary biopsy. Each has been used with success in various body sites. Recently, a comparison of these two techniques showed no significant difference with regard to specimen adequacy. In this study, the type of technique was correlated with diagnostic accuracy. For each technique, the preoperative cytology diagnosis was compared with the surgical pathology diagnosis in 46 resected thyroid nodules. No false-positive diagnoses were identified. No significant difference in diagnostic accuracy was found on comparison of the two techniques. Therefore, either technique may be used according to the operator's preference.
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