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Operantly conditioned plasticity in spinal cord.

J R Wolpaw1, C L Lee, J S Carp

  • 1Wadsworth Center for Laboratories and Research, New York State Department of Health, State University of New York, Albany 12201.

Annals of the New York Academy of Sciences
|January 1, 1991
PubMed
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The spinal stretch reflex (SSR) pathway can be operantly conditioned, with plasticity occurring in the spinal cord. This simple vertebrate central nervous system (CNS) pathway offers a model for studying learning-related neural changes.

Area of Science:

  • Neuroscience
  • Motor Control
  • Learning and Memory

Background:

  • The monosynaptic pathway of the spinal stretch reflex (SSR) is a fundamental component of motor control.
  • Recent research indicates that this pathway can undergo operant conditioning, suggesting neural plasticity.
  • A significant portion of this plasticity is localized within the spinal cord.

Purpose of the Study:

  • To investigate the sites of activity-driven plasticity within the SSR pathway responsible for behavioral changes.
  • To establish the SSR pathway as a model for understanding activity-driven central nervous system (CNS) changes related to learning.

Main Methods:

  • Operant conditioning of the monosynaptic SSR pathway.
  • Investigation of plasticity at the Ia afferent neuron-motoneuron synapse and/or the motoneuron itself.

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Main Results:

  • The monosynaptic SSR pathway demonstrates operant conditionability.
  • Plasticity underlying behavioral changes is significantly located within the spinal cord.
  • Potential sites for this plasticity include the Ia afferent synapse on the motoneuron and/or the motoneuron.

Conclusions:

  • The SSR pathway's simplicity and accessibility make it an ideal model for studying activity-driven CNS plasticity.
  • Understanding plasticity in the SSR pathway can elucidate fundamental mechanisms of learning in the CNS.