Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 29, 2026

A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains
05:12

A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains

Published on: November 8, 2018

A method for localizing microelectrode trajectories in the macaque brain using MRI.

Rishi M Kalwani1, Luke Bloy, Mark A Elliott

  • 1Department of Neuroscience, University of Pennsylvania, 116 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6074, United States.

Journal of Neuroscience Methods
|October 4, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys.

eLife·2026
Same author

Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex.

bioRxiv : the preprint server for biology·2026
Same author

An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

Aperture neuro·2026
Same author

The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.

bioRxiv : the preprint server for biology·2026
Same author

Impaired intrinsic motivation in psychosis risk relates to ventral striatum activation to self-generated reinforcement signals.

Schizophrenia research·2026
Same author

Information-seeking decision strategies mitigate risk in dynamic, uncertain environments.

Journal of the Royal Society, Interface·2026
Same journal

Pupil-DLC: an open-source deep learning pipeline for scalable, marker-less tracking of pupil dynamics across conscious and unconscious states.

Journal of neuroscience methods·2026
Same journal

Time as the language of Behavior: events, sequences, patterns and meanings.

Journal of neuroscience methods·2026
Same journal

Detection of cochlear microphonic for differential diagnosis between auditory neuropathy mice and noise-induced sensorineural hearing loss mice.

Journal of neuroscience methods·2026
Same journal

Assessment metrics for pain control in rats: A methodological commentary.

Journal of neuroscience methods·2026
Same journal

Infant EEG preprocessing pipelines: A capability framework and current gaps in practice.

Journal of neuroscience methods·2026
Same journal

Methods for measuring neural activity during voluntary wheel running.

Journal of neuroscience methods·2026
See all related articles

This study introduces a novel method for precisely locating brain targets using MRI. It enables accurate 3D quantification of microelectrode trajectories for electrophysiology research.

Area of Science:

  • Neuroscience
  • Electrophysiology
  • Medical Imaging

Background:

  • Magnetic resonance imaging (MRI) is crucial for electrophysiologists targeting specific brain regions.
  • Current limitations exist in quantifying 3D locations of brain structures, recording chambers, and microelectrode paths.

Purpose of the Study:

  • To present a new method for accurately quantifying the 3D relative locations of brain structures, recording chambers, and microelectrode trajectories using MRI.
  • To overcome the limitations of existing techniques in precise targeting for electrophysiological recordings.

Main Methods:

  • Surgically implanted recording chambers are fitted with a contrast-agent-filled cylinder for MRI segmentation.
  • A virtual cylinder is projected along the microelectrode's trajectory through the 3D MRI brain volume.

More Related Videos

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment
09:30

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment

Published on: May 23, 2025

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus)
10:53

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus)

Published on: September 29, 2019

Related Experiment Videos

Last Updated: Jun 29, 2026

A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains
05:12

A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains

Published on: November 8, 2018

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment
09:30

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment

Published on: May 23, 2025

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus)
10:53

Stereotaxic Surgery for Implantation of Microelectrode Arrays in the Common Marmoset (Callithrix jacchus)

Published on: September 29, 2019

  • This technique bypasses the need for stereotaxic coordinate systems.

    • Main Results:

    • The method allows for quantification of recording chamber coverage relative to anatomical landmarks at any depth or orientation.
    • Successfully localized macaque cortex regions (middle temporal area, lateral intraparietal area, frontal eye field) and the locus coeruleus for recordings.
    • Integrated with brain-mapping software like Caret and AFNI.

    Conclusions:

    • The developed technique enhances the precision of targeting brain regions for electrophysiological recordings.
    • It offers a versatile and accurate solution for 3D localization in neuroscientific research.
    • Facilitates detailed anatomical localization without reliance on stereotaxic atlases.