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Enhanced gene amplification in human cells knocked down for DNA-PKcs

Alberto Salzano1, Nino Kochiashvili, Solomon G Nergadze

  • 1Dipartimento di Genetica e Microbiologia "Adriano Buzzati-Traverso", Università di Pavia, Via Ferrata 1, 27100 Pavia, Italy.

DNA Repair
|October 4, 2008
PubMed
Summary

Inhibiting DNA-PKcs in human cells enhances gene amplification, particularly through double minutes, a key mechanism for drug resistance. This highlights DNA-PKcs

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