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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Human bocavirus infection in children with respiratory tract disease

Nathalie Brieu1, Gaël Guyon, Michel Rodière

  • 1Department of Virology, Montpellier University Hospital, Montpellier Cedex, France.

The Pediatric Infectious Disease Journal
|October 4, 2008
PubMed

Insights

Human bocavirus (HBoV) is linked to respiratory tract disease (RTD) in children, with higher detection rates in ill children than controls. HBoV infections presented similar symptoms to RSV and HMPV but were less severe than RSV.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Human bocavirus (HBoV) is a Parvoviridae family member frequently found in children's respiratory tracts.
  • Limited data exists linking HBoV to respiratory tract disease (RTD).

Purpose of the Study:

  • Evaluate HBoV incidence in children with RTD.
  • Analyze clinical features of HBoV infection.
  • Compare HBoV, RSV, and HMPV infections clinically.

Main Methods:

  • Prospective 1-year study.
  • Included children under 5 hospitalized with RTD and asymptomatic controls.

Main Results:

  • HBoV detected in 10.8% of children with RTD, none in controls (P=0.01).
  • Most infections occurred November-March; 40% had coinfections.
  • HBoV viral load higher in monoinfections; clinical features similar to RSV/HMPV but less severe than RSV.

Conclusions:

  • HBoV prevalence in RTD patients supports its role in disease.
  • Frequent coinfections may relate to HBoV persistence.
  • Further research needed on HBoV viral load as a pathogenicity marker.
Abstract

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