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Stability of aqueous perchlorate formulations
American Journal of Hospital Pharmacy
|January 1, 1977
Summary
Aqueous perchlorate formulations for nuclear medicine are stable for at least nine months. Potassium perchlorate solutions should be stored at room temperature, while sodium perchlorate solutions can be refrigerated.
Area of Science:
- Nuclear medicine
- Pharmaceutical sciences
- Analytical chemistry
Background:
- Perchlorate formulations are utilized in nuclear medicine.
- Understanding the stability of these formulations under various storage conditions is crucial for effective clinical application.
- Key perchlorate formulations include intravenous potassium perchlorate, oral sodium perchlorate-sorbitol, and oral potassium perchlorate in cherry syrup.
Purpose of the Study:
- To evaluate the stability of three distinct aqueous perchlorate formulations.
- To determine the impact of formulation type and storage temperature on perchlorate stability.
- To provide storage recommendations for these nuclear medicine formulations.
Main Methods:
- Gravimetric analysis was employed to determine perchlorate concentration.
- Precipitation with tetra-n-pentylammonium bromide was the core analytical technique.
- Stability was assessed over time under controlled storage conditions.
Main Results:
- All three aqueous perchlorate formulations demonstrated stability for a minimum of nine months.
- Potassium perchlorate formulations showed potential for precipitation upon refrigeration.
- Sodium perchlorate formulations exhibited greater solubility and were suitable for refrigeration.
Conclusions:
- Aqueous perchlorate formulations are generally stable for extended periods (≥9 months).
- Refrigeration is not recommended for potassium perchlorate formulations due to potential precipitation.
- Sodium perchlorate formulations offer flexibility in storage, including refrigeration, owing to their higher solubility.