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Updated: Jun 29, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors
Artur Muradyan1, Vivien Boldt, Anne Steininger
1Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Abstract:
The accumulation of chromosomal aberrations is a characteristic feature of tumor development. However, an understanding of tumorigenesis that assumes that changes in DNA copy number always cause equivalent changes in the corresponding RNA and protein levels is an oversimplification and completely ignores the individual genetic and epigenetic context in which an aberration has to be evaluated. We present a brief introduction to various techniques dedicated to the genome-wide analysis of genetic and epigenetic changes, and illustrate how complementary information derived from these various DNA array-based technologies can lead to a better understanding of the consequences of chromosomal aberrations.
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