Related Experiment Video
Updated: Jun 29, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Vessel masking improves densitometric myocardial perfusion assessment
Tamás Ungi1, Zsolt Zimmermann, Erika Balázs
1Department of Radiology, Medical Faculty, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary.
Introduction:
The objective of treatment in acute myocardial infarction (AMI) is reperfusion of the myocardium at risk. Our goal was to evaluate the effect of vessel masking on videodensitometric assessment of myocardial reperfusion.
Methods:
Epicardial vessels were masked out from the densitometric region of interest, where average rise slope (G(max)/T(max)) of time-density curves (TDC) were measured. Measurements were tested to detect indicators of reperfusion as cumulative creatine-kinase (CK) release and ST-resolution by receiver operating characteristic (ROC) curve analysis.
Results:
When vessel masking was applied before G(max)/T(max) measurement, an improvement has been observed in sensitivity and area under ROC curve to detect indicators of reperfusion as cumulative enzyme release (sensitivity (Se): 85% vs. 61%, area under the curve (AUC): 0.84 vs. 0.76) and ST-resolution (Se: 74% vs. 67%, AUC: 0.83 vs. 0.79).
Conclusions:
Selective myocardial perfusion measurement on coronary angiograms is feasible and serves as an informative method to detect myocardial viability after AMI and revascularization therapy. The present study demonstrated that vessel masking improves results compared to simple densitometric analysis.
