Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Post Hoc Subgroup Analysis by Disease Severity in a Non-Inferiority Trial of Donepezil 27.5 mg Transdermal Formulation in Japanese Patients With Mild-to-Moderate Alzheimer Disease.

Alzheimer disease and associated disorders·2026

Same author

Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis.

BMC medicine·2026

Same author

C4orf3 Regulates HIF-1α Degradation Under Hypoxic Conditions and Contributes to the Malignant Phenotype in Small Cell Lung Cancer.

Journal of Cancer·2026

Same author

Gastric-Type Adenomas of the Nonampullary Duodenum: Reappraisal of Clinicopathological and Molecular Features and a Proposal for Novel Classification.

The American journal of surgical pathology·2026

Same author

Paralytic Ileus as the Initial Manifestation of New-Onset Type 1 Diabetes Without Diabetic Ketoacidosis: A Case Report.

Cureus·2026

Same author

[A Case of Hormone Receptor-Positive, HER2-Negative Metastatic Recurrent Breast Cancer Successfully Treated with Capivasertib and Fulvestrant in Late-Line Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

Search research articles

Related Experiment Video

Updated: Jun 29, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Rhabdomyosarcoma masquerading as acute leukemia.

Yuichi Shinkoda¹, Yoshihisa Nagatoshi, Reiji Fukano

¹Section of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan.

Pediatric Blood & Cancer

|October 8, 2008

Summary

Rarerhabdomyosarcoma (RMS) can mimic acute leukemia (AL). Immunohistochemistry is crucial for diagnosing RMS in bone marrow when flow cytometry shows unusual cell surface antigen results.

More Related Videos

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Related Experiment Videos

Last Updated: Jun 29, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Area of Science:

Oncology
Hematology
Pathology

Background:

Rhabdomyosarcoma (RMS) is a rare soft tissue sarcoma.
Acute leukemia (AL) is a hematological malignancy characterized by blast cells in the bone marrow.
Distinguishing RMS presenting as AL is diagnostically challenging.

Observation:

Three cases of rhabdomyosarcoma (RMS) mimicking acute leukemia (AL) were identified.
Patients presented with bone marrow infiltration by blast-like cells, lacking typical myeloid or lymphoid surface antigens.
No overt symptoms of solid tumors were present in these cases.

Findings:

Bone marrow analysis revealed approximately 95% abnormal blast-like cells.
Immunohistochemistry confirmed the expression of actin, desmin, and myoglobin, indicative of RMS.
Flow cytometry results showed an unusual immunophenotype, not fitting typical leukemia profiles.

Implications:

Immunohistochemistry is essential for accurate diagnosis of rhabdomyosarcoma in bone marrow.
This diagnostic approach is critical when flow cytometry presents atypical findings.
Early and accurate diagnosis of RMS presenting as AL improves patient management and outcomes.