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Rosaceiform eruption induced by erlotinib.

Annalisa Patrizi¹, Federica Bianchi, Iria Neri

¹Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University of Bologna, Italy. annalisa.patrizi@unibo.it

Dermatologic Therapy

|December 17, 2008

Summary

Anti-EGFR therapy can cause skin issues like acneiform eruptions. This case highlights a rosaceiform eruption from erlotinib, possibly linked to Demodex mites.

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Area of Science:

Dermatology
Oncology

Background:

Anti-epidermal growth factor receptor (EGFR) therapies are crucial in cancer treatment.
Cutaneous adverse events are common, with acneiform eruptions affecting over 50% of patients.

Observation:

An 81-year-old male patient developed a rosaceiform eruption during erlotinib treatment.
Skin scraping revealed the presence of Demodex folliculorum mites.

Findings:

Erlotinib, an anti-EGFR agent, can induce rosaceiform eruptions.
Demodex folliculorum mites may play a role in the pathogenesis of these eruptions.

Implications:

This case expands the understanding of EGFR inhibitor-induced skin toxicities.
Further research into the role of Demodex mites in anti-EGFR therapy adverse events is warranted.

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