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Rosaceiform eruption induced by erlotinib

Annalisa Patrizi1, Federica Bianchi, Iria Neri

  • 1Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University of Bologna, Italy. annalisa.patrizi@unibo.it

Dermatologic Therapy
|December 17, 2008
PubMed

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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...