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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...

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Isolation of microRNAs from Tick Ex Vivo Salivary Gland Cultures and Extracellular Vesicles
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Isolation of microRNAs from Tick Ex Vivo Salivary Gland Cultures and Extracellular Vesicles

Published on: April 6, 2022

CoGemiR: a comparative genomics microRNA database.

Vincenza Maselli1, Diego Di Bernardo, Sandro Banfi

  • 1TIGEM Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples Italy. maselli@tigem.it

BMC Genomics
|October 8, 2008
PubMed
Summary
This summary is machine-generated.

CoGemiR is a new database offering a comparative genomics view of microRNA organization and conservation across species. It integrates existing data and predicts new microRNAs, aiding in understanding microRNA biology.

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Last Updated: Jun 29, 2026

Isolation of microRNAs from Tick Ex Vivo Salivary Gland Cultures and Extracellular Vesicles
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Published on: April 6, 2022

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • MicroRNAs are key regulators of gene expression, binding to target mRNAs.
  • MicroRNAs can be encoded within host genes or intergenic regions with independent regulatory elements.
  • Existing databases lack comprehensive evolutionary genomic organization data for microRNAs.

Purpose of the Study:

  • To develop a database for exploring microRNA genomic organization and evolutionary conservation.
  • To provide a comparative genomics overview of microRNA structure across metazoan species.

Main Methods:

  • Integrated data from existing microRNA databases.
  • Developed a microRNA prediction pipeline for annotating new microRNAs.
  • Collected and organized genomic location, conservation, and expression data.

Main Results:

  • Launched CoGemiR, a publicly available, microRNA-centered database.
  • CoGemiR offers a comparative view of microRNA genomic organization and conservation.
  • Identified previously unannotated microRNAs in several species.

Conclusions:

  • CoGemiR facilitates understanding microRNA biology through comparative genomics.
  • The database provides a user-friendly web interface for exploring microRNA genomic context across species.
  • CoGemiR integrates diverse data to offer novel insights into microRNA evolution.