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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

The IMGT/HLA database.

James Robinson¹, Matthew J Waller, Sylvie C Fail

¹Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.

Nucleic Acids Research

|October 8, 2008

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The IMGT/HLA database, a key resource for human leukocyte antigen (HLA) research, has been updated for 10 years. It now offers over 3300 curated HLA sequences and enhanced bioinformatics tools for the scientific community.

Area of Science:

Immunogenetics
Bioinformatics
Genomics

Background:

The Human Leukocyte Antigen (HLA) complex, located on chromosome 6p21.3, comprises over 220 genes crucial for immune function.
Many HLA genes are highly polymorphic, playing a vital role in immune response and transplantation.
Accurate nomenclature and quality control of HLA genes and alleles are managed by the WHO Nomenclature Committee.

Purpose of the Study:

To provide a continuously updated, searchable repository of curated HLA sequences.
To offer advanced bioinformatics tools for sequence analysis and primer design.
To ensure public access to the latest HLA data for research and clinical applications.

Main Methods:

Curating and maintaining a comprehensive database of HLA sequences.

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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Developing and updating web-based bioinformatics tools for data analysis.

Collaborating with the European Bioinformatics Institute for public data dissemination.

Main Results:

The IMGT/HLA database has grown from 964 sequences in its first release to over 3300 sequences.
Approximately 450 new HLA sequences are added annually, ensuring data relevance.
Enhanced tools now support complex alignments with genomic data and facilitate probe/primer design.

Conclusions:

The IMGT/HLA database serves as an essential resource for the HLA research and clinical communities.
Regular updates and improved tools enhance the utility of the database for diverse applications.
Public accessibility via the EBI website facilitates widespread use and advancement in HLA-related research.