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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 29, 2026

Infinium Assay for Large-scale SNP Genotyping Applications

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

Medium- to high-throughput SNP genotyping using VeraCode microbeads.

Charles H Lin¹, Joanne M Yeakley, Timothy K McDaniel

¹Illumina, Inc., San Diego, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|October 8, 2008

Summary

This summary is machine-generated.

New SNP genotyping technology offers flexible, high-throughput analysis for genetic variation and disease research. This platform aids biomarker discovery and molecular diagnostics development.

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Last Updated: Jun 29, 2026

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Area of Science:

Genetics
Genomics
Biotechnology

Background:

Multiplexed single nucleotide polymorphism (SNP) genotyping advances enable large-scale genetic variation and disease association studies.
Whole-genome association studies identify genetic markers, necessitating focused SNP analysis for validation and research.

Purpose of the Study:

Introduce a novel SNP genotyping platform with flexible assay content and multiplexing capabilities.
Highlight the platform's suitability for medium- to high-throughput applications in genetic research.

Main Methods:

Utilizes the Illumina BeadXpress platform with the GoldenGate Genotyping Assay.
Employs digitally inscribed VeraCode microbeads for streamlined workflow and rapid detection.

Main Results:

The platform supports up to 384 analytes, offering flexibility in assay design.
Demonstrates streamlined workflow, rapid detection, and high data reproducibility and consistency.

Conclusions:

The BeadXpress platform is a valuable tool for biomarker research and validation.
Facilitates pharmaceutical development and the creation of molecular diagnostic tests.