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Related Experiment Video

Updated: Jun 29, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

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Published on: September 28, 2015

[Hereditary angioedema--pathophysiology, genetics, symptoms].

Agnieszka Muszyńska¹, Ewa Janocha, Andrzej M Fal

¹Department of Family Medicine, Medical University of Wrocław, Poland.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego

|October 9, 2008

Summary

Hereditary angioedema (HAE) is a rare genetic disorder causing severe swelling. This review covers its epidemiology, pathophysiology, genetics, and diagnostic challenges.

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Area of Science:

Immunology
Genetics

Context:

Hereditary angioedema (HAE) is a rare genetic disorder.
Characterized by recurrent, life-threatening swelling attacks.
Often presents diagnostic and therapeutic challenges.

Purpose:

To provide a comprehensive overview of Hereditary Angioedema (HAE).
Discuss epidemiology, pathophysiology, genetics, and classification.
Review clinical symptoms, diagnosis, and HAE type differentiation.

Summary:

HAE results from C1 esterase inhibitor deficiency, leading to uncontrolled complement and contact system activation.
Vasoactive mediators, primarily bradykinin, cause localized, massive edema.
Symptoms include recurrent swelling of submucosal and subcutaneous tissues, potentially affecting skin and visceral organs.

Impact:

Enhances understanding of HAE's complex mechanisms.
Aids in recognizing diverse clinical presentations.
Supports improved diagnostic and therapeutic strategies for HAE patients.