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Published on: August 30, 2014
EFFICACY AND SAFETY OF CANDELABRA ALOE EXTRACT (ALOE ARBORESCENS MILL.) IN PREVENTION AND TREATMENT OF UPPER
Karina Schönknecht1, Anna Maria Kulawik2, Hanna Krauss3
1FACULTY OF EDUCATIONAL STUDIES, KAZIMIERA MILANOWSKA COLLEGE OF EDUCATION AND THERAPY IN POZNAN, POZNAN, POLAND; SCIENTIFIC INFORMATION DEPARTMENT, PHYTOPHARM KLEKA SA, NOWE MIASTO NAD WARTA, POLAND.
Insights
Aloe arborescens extract (AA) effectively reduced upper respiratory tract infection symptoms in children. Carers reported high satisfaction with AA
Area of Science:
- Pediatric Medicine
- Phytotherapy
- Infectious Diseases
Background:
- Upper respiratory tract infections (URIs) are common in children.
- Effective and safe treatments for pediatric URIs are in demand.
- Aloe arborescens (AA) is a plant with potential therapeutic properties.
Purpose of the Study:
- To evaluate the therapeutic effects of Aloe arborescens extract (AA) in children aged 3-18 with URIs.
- To assess carer satisfaction with AA treatment for pediatric URIs.
- To determine AA's impact on appetite in children.
Main Methods:
- A large-scale study involving 6764 children (3-18 years) across 237 centers.
- Conducted by 279 pediatric and family medicine specialists.
- Efficacy assessed by symptom reduction using chi-square test.
Main Results:
- Significant symptom reduction observed: 81% for sore throat/hoarseness, 72% for earache, 64% for nasal symptoms, 63% for cough, 89% for fever, 82% for sleep disturbances.
- Over 66% of children showed improved appetite.
- Nearly 60% of carers were very satisfied with AA's efficacy.
Conclusions:
- Aloe arborescens extract (AA) demonstrates high efficacy in reducing URI symptoms in children.
- Pediatric patients and their carers are satisfied with AA's therapeutic effects for all indicated uses.
- AA is a well-tolerated option with high recommendation rates.
Objective:
The aim: To evaluate therapeutic effects of a product containing Aloe arborescens extract (AA) as the active substance in children aged 3-18 years with a diagnosed viral or bacterial upper respiratory tract infection and to assess their carers' satisfaction with the use of the product. The above-mentioned product is also indicated to control the loss of appetite. Thus, the study also assessed the effect of AA on this parameter.
Patients And Methods:
Materials and methods: A total of 6764 patients (children aged 3-18 years) were included in the study, which was conducted by 279 paediatrics and family medicine specialists (or being in the course of specialisation) from 237 centres. The efficacy was evaluated of the basis of reduction of upper respiratory tract infections (URIs) symptoms between the first and second visits with the application of the chi-square test.
Results:
Results: The most common primary diagnoses for which AA was used were common colds and recurrent acute URIs of viral aetiology. Symptoms reduction or resolution were reported in over: 81% of children with sore throat and/or hoarseness, 72% of children with earache, 64% of children with nasal discharge and/or the feeling of congested nose, 63% of children with cough, 89% of children with fever and 82% of children with sleep disturbances. Improvement in appetite was achieved in more than 66% of children. Almost 60% of the paediatric patients or their carers included in the study group were very satisfied with the efficacy of AA. More than 66% of carers were very satisfied with the dosing regimen and the vast majority of them (99%) would recommend the preparation to others. Two children demonstrated adverse effects (diarrhoea, abdominal pain) that were induced by application of the studied product. They resolved after its discontinuation.
Conclusion:
Conclusions: AA applied in treatment of URIs in children highly effectively reduces symptoms of the diseases. Paediatric patients and their carers are satisfied with therapeutic effects of the syrup with regards to its all indications.
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