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Related Experiment Video

Updated: Jun 29, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Modeling endotoxin-induced systemic inflammation using an indirect response approach.

P T Foteinou1, S E Calvano, S F Lowry

  • 1Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.

Mathematical Biosciences
|October 9, 2008
PubMed
Summary
This summary is machine-generated.

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This study proposes a computational model for endotoxin-induced inflammation, simulating receptor-mediated responses and transcriptional changes. The model captures various inflammatory scenarios, including tolerance and potentiation, offering insights into innate immune system dynamics.

Area of Science:

  • Immunology
  • Computational Biology
  • Systems Biology

Background:

  • Endotoxin triggers innate immune responses via receptor-mediated signaling.
  • Inflammation involves complex downstream signal transduction and transcriptional changes.
  • Understanding these dynamics is crucial for modeling inflammatory diseases.

Purpose of the Study:

  • To develop an in silico model of receptor-mediated endotoxin-induced inflammation.
  • To couple extracellular signals with transcriptional responses.
  • To simulate and analyze various inflammatory scenarios and their underlying mechanisms.

Main Methods:

  • Development of a receptor-mediated indirect response model.
  • In silico simulation using eight (8) variables.

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Published on: May 2, 2018

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
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A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Related Experiment Videos

Last Updated: Jun 29, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

  • Evaluation of biologically relevant scenarios: self-limited, persistent infectious, and persistent non-infectious inflammation.
  • Analysis of endotoxin tolerance and potentiation effects.

    • Main Results:

    • The model successfully simulates non-linear inflammatory behaviors.
    • It differentiates between self-limited and persistent inflammatory responses.
    • It demonstrates the capacity to model complex phenomena like endotoxin tolerance and potentiation.

    Conclusions:

    • The proposed in silico model provides a framework for studying endotoxin-induced inflammation.
    • It aids in understanding the dynamics of innate immune system activation and response.
    • The model has potential applications in predicting inflammatory outcomes and therapeutic interventions.