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Hepatitis

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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Related Experiment Video

Updated: Jun 29, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Hepatitis B virus genotypes: an overview.

Mamun-Al Mahtab¹, Salimur Rahman, Mobin Khan

¹Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. shwapnil@agni.com

Hepatobiliary & Pancreatic Diseases International : HBPD INT

|October 10, 2008

Summary

This summary is machine-generated.

Hepatitis B virus (HBV) genotypes influence disease severity and treatment response. Future HBV treatment may routinely involve genotyping, similar to Hepatitis C virus (HCV).

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Last Updated: Jun 29, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

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Published on: June 5, 2020

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Area of Science:

Hepatology
Virology
Infectious Diseases

Background:

Hepatitis B virus (HBV) infection is a significant global health concern, causing substantial mortality and morbidity.
Identifying viral factors influencing HBV disease progression, severity, and treatment outcomes is crucial.
HBV exhibits genetic variations, leading to its classification into distinct genotypes.

Purpose of the Study:

To review the impact of Hepatitis B virus genotypes on clinical outcomes.
To explore the potential role of HBV genotyping in guiding treatment strategies.

Main Methods:

A comprehensive review of existing published literature on HBV genotypes was conducted.

Main Results:

HBV genotypes are strongly associated with the severity and progression of HBV-induced liver disease.
Viral genotypes appear to influence patient responses to various antiviral therapies.
Genotype-specific differences may impact the efficacy of antiviral agents.

Conclusions:

Current clinical practice does not routinely recommend HBV genotyping for treatment.
Emerging evidence suggests HBV genotyping may become a standard diagnostic tool for HBV infection management.
Similar to Hepatitis C virus (HCV) management, HBV genotyping is anticipated to play a more prominent role in future therapeutic decisions.