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Related Experiment Video

Updated: Jun 29, 2026

Quantification of Acanthamoeba spp. Motility

Quantification of Acanthamoeba spp. Motility

Published on: September 20, 2024

Acanthamoeba sclerokeratitis.

Katayoon B Ebrahimi¹, W Richard Green, Rhonda Grebe

¹Eye Pathology Laboratory and Cornea/External Disease Service, Wilmer Eye Institute and Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie

|October 10, 2008

Summary

This summary is machine-generated.

Acanthamoeba scleritis, a severe complication of acanthamoeba keratitis, can involve scleral invasion. This case highlights Acanthamoeba trophozoites in the sclera, potentially driving inflammation and necrotizing scleritis.

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Quantification of Acanthamoeba spp. Motility

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Published on: September 20, 2024

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Area of Science:

Ophthalmology
Infectious Diseases
Pathology

Background:

Acanthamoeba keratitis can lead to Acanthamoeba scleritis, a severe ocular complication.
This study details a case of Acanthamoeba sclerokeratitis following prior treatment for Acanthamoeba keratitis.

Observation:

A patient with a history of penetrating keratoplasty for Acanthamoeba keratitis developed nodular necrotizing scleritis.
Viable Acanthamoeba was cultured from the affected scleral tissue.
The patient underwent enucleation due to persistent Acanthamoeba sclerokeratitis.

Findings:

Histopathology confirmed Acanthamoeba invasion into the sclera.
Trophozoites were identified in the scleral tissue, though not at the cryotherapy site.
The presence of Acanthamoeba trophozoites in the sclera is linked to immune response exacerbation.

Implications:

This case provides evidence of Acanthamoeba organisms invading scleral tissue.
Scleral invasion by Acanthamoeba may contribute to the development of nodular scleritis.
Understanding this pathway is crucial for managing severe Acanthamoeba infections of the eye.