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Isodicentric chromosome 18q as sole abnormality in a histologically normal bone marrow from a patient with diffuse
D H Wurster-Hill1, J J Vredenburgh, B H Davis
1Dartmouth-Hitchcock Medical Center, Durham, North Carolina.
Cancer Genetics and Cytogenetics
|July 15, 1991
Abstract:
Cytogenetic analysis was performed on the histologically and immunophenotypically normal bone marrow (BM) of a 33-year-old woman with non-Hodgkin's lymphoma (NHL) before BM harvest. Unstimulated 24- and 48-hour cultures produced only normal metaphases. A pokeweed mitogen (PWM)-stimulated 48-hour culture, however, showed a clonal isodicentric chromosome 18q as the sole abnormality, suggesting a role for this approach in detection of submicroscopic BM involvement by B-cell NHL.