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Cervical lymphadenopathy: scrofula revisited
R Khan1, S H Harris, A K Verma
1Department of Pathology, J N Medical College, Aligarh Muslim University, Uttar Pradesh, India.
The Journal of Laryngology and Otology
|October 11, 2008
Summary
Tubercular cervical lymphadenitis, a common extrapulmonary tuberculosis, is best diagnosed with fine needle aspiration cytology. A six-month course of anti-tubercular drugs effectively cures the condition without surgery.
Area of Science:
- Infectious Diseases
- Pulmonology
- Oncology
Background:
- Tubercular cervical lymphadenitis (scrofula) is the most frequent extrapulmonary tuberculosis.
- This study investigates the clinical presentation, diagnosis, and management of cervical lymphadenopathy.
Purpose of the Study:
- To analyze the characteristics of tubercular cervical lymphadenitis.
- To evaluate diagnostic methods and treatment outcomes.
Main Methods:
- Retrospective analysis of 1827 patients with cervical lymphadenopathy over three years.
- Fine needle aspiration cytology (FNAC) and Polymerase Chain Reaction (PCR) were used for diagnosis.
- Treatment involved a six-month course of anti-tubercular drugs.
Main Results:
- 48.87% of patients had tubercular lesions.
- Unilateral, matted adenopathy in young females without constitutional symptoms was common.
- FNAC yielded positive results in 90% of cases; PCR sensitivity was 63%.
- Only 18% had associated pulmonary tuberculosis; most had isolated cervical involvement.
Conclusions:
- Fine needle aspiration cytology is a simple, cost-effective diagnostic tool for tubercular cervical lymphadenitis.
- A short course of anti-tubercular chemotherapy can achieve complete cure without surgery.
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