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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Oscillating signaling pathways during embryonic development.

Alexander Aulehla1, Olivier Pourquié

  • 1Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA. ala@stowers-institute.org

Current Opinion in Cell Biology
|October 11, 2008
PubMed
Summary
This summary is machine-generated.

Embryonic development involves oscillating signaling pathways, initially observed in vertebrate somite formation. Recent studies suggest the core mechanism for these oscillations remains undiscovered, challenging previous models.

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Optogenetic Signaling Activation in Zebrafish Embryos
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Last Updated: Jun 29, 2026

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

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Optogenetic Signaling Activation in Zebrafish Embryos
07:18

Optogenetic Signaling Activation in Zebrafish Embryos

Published on: October 27, 2023

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Genetics

Background:

  • Oscillatory signaling pathway activity was first identified in vertebrate somite formation.
  • This process was thought to be regulated by Notch, FGF, and Wnt pathways.
  • Recent genetic studies challenge the role of these pathways as the primary oscillation pacemakers.

Purpose of the Study:

  • To investigate the underlying mechanisms of oscillatory gene activity during embryonic development.
  • To explore the broader function of oscillatory signaling beyond somite formation.

Main Methods:

  • Review of recent genetic studies on embryonic development.
  • Analysis of oscillatory gene activity in distinct developmental processes.

Main Results:

  • The core pacemaker for somite formation oscillations is unlikely to involve periodic activation by Notch, FGF, and Wnt pathways.
  • Oscillatory signaling, particularly Notch pathway-related, is involved in chick limb development and mouse neural progenitor maintenance.
  • This suggests a more general role for oscillatory signaling in embryonic development.

Conclusions:

  • The precise mechanism driving somite formation oscillations remains to be discovered.
  • Oscillatory signaling pathways play a potentially broader role in embryonic development than previously understood.
  • Notch pathway oscillations are implicated in diverse developmental processes.